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doi:10.1016/s1383-5742(00)00050-8

Several studies have shown that LA supplementation significantly decreases hepatic lipid accumulation and function in a normal MCD diet and a hypercaloric MCD diet (Table 6)

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Examination of electron transport chain function in muscle and fibroblast culture, histological and electron microscopy examination of muscle and other biomarkers of mitochondrial metabolism revealed a pattern consistent with the notion that PPA could be interfering with mitochondrial metabolism at the level of the tricarboxylic-acid cycle (TCAC)