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All participants, investigators and the sponsor were masked to treatment assignment

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The evidence now is reassuring: A 2025 meta-analysis in JAMA Psychiatry found no increase in depression or suicidality with GLP-1 medications versus placebo FDA and EMA reviews found no causal link between GLP-1s and suicidal behavior In fact, GLP-1-treated groups showed slightly lower rates of depressive symptoms in clinical trials (likely due to improved metabolic health and quality of life) Potential mental health benefits under investigation: Reduced binge-eating impulses Decreased cravings in substance use disorders Improved mood independent of weight loss (possibly via reduced inflammation and effects on brain reward circuits) Bottom line: With appropriate monitoring, psychiatrists can feel confident that adding a GLP-1 wont destabilize a patients mental state and may improve it

Studies indicate that higher protein intake during weight loss preserves lean mass and improves metabolic function