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However, focal seizures may often cause bilateral pupillometric changes due to rapid seizure generalization (so that the majority of the seizure episode consists of a generalized seizure)

[6] The concern with any unregulated IGF-1R agonist is precisely that it could stimulate the survival and proliferation of pre-neoplastic or neoplastic cells, which is why IGF-1R has been an oncology drug target for inhibition rather than activation

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