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None of that changes whats happening in the dermal layer where collagen is produced, where cells divide, and where the structural decisions that determine skin firmness, texture, and healing speed are made

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Older individuals undergoing massive weight loss are likelier to experience sagging skin

Additionally, magnetic resonance imaging (MRI) conducted on a subset of participants from the SURPASS-3 trial showed that, after 52 weeks of treatment with tirzepatide, liver fat content was reduced by 30% or more in 67% to 79% of participants, and VAT volume decreased by 16% to 25% [62]