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Autophagy plays an essential role in mitigating these pathological processes by removing damaged organelles, including lipid droplets, and suppressing inflammasome activation

PubMed record Monti JM, Debellis J, Alterwain P, Pellejero T, Monti D

According to NICE guidance and standard UK clinical practice, patients with confirmed B12 deficiency and neurological symptoms typically require initial treatment with hydroxocobalamin injections

Furthermore, disease-associated changes in active histone marks such as H3K27ac and H3K4me3 correlate with transcriptional shifts in reactive astrocytes, particularly in genes associated with synaptic dysfunction, tau pathology and A processing