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For example, the second major repressor of Nrf2 that has been discovered is the -transducin repeat-containing protein (-TrCP) ( 3 Nrf2 is involved in the regulation of periodontal disease 3.1 Nrf2, lipid peroxidation and periodontal disease Among the factors that cause oxidative stress in cells, lipid oxidative modification in the lipid bilayer, especially lipid peroxidation, has become an important regulatory factor that determines the fate of cells ( ), and remove a hydrogen from another PUFA to form PLOOH ( Cells also have a system to prevent LPO