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23 These results, combined with imaging studies showing both an increased functional response of the hypothalamus to food stimuli, 24 the involvement of the amygdala, 25 and the reduced coupling of the ventral striatum with limbic structures for basic internal homeostasis, 26 suggest a crucial role of several brain areas in the abnormal regulation of food intake in PWS

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Development of a new agent from discovery to market usually takes about 1012 years, but this timespan can vary significantly