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These symptoms may appear gradually and should not be ignored, especially when they persist or worsen over time

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However, because the lips are constantly in motion and we often "eat" our lip products throughout the day, topical application alone may not be enough to sustain high levels of the nutrient in the skin tissue

Urine samples collected for the measurement of F 2 -IsoPs were stored at 80C prior to shipment to Vanderbilt Eicosanoid Core Laboratory (Nashville, Tennessee, USA) for quantification of F 2 -IsoPs F 2 (PGF 2 ), free 8-iso-prostaglandin F 2 (8-iso-PGF 2 ), 2,3-dinor-5,6-dihydro-15-F 2t -IsoP and 5-series F 2 -IsoP by GC-negative ion chemical ionisation-MS employing stable isotope dilution as described in Milne et al