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While vitamin B12 naturally occurs in the body, making allergic reactions to it exceedingly rare, certain additives or preservatives in some preparations could cause mild localized reactions, such as redness or itching

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The main mechanism underlying this phenomenon is the loss of the suppressive activity of insulin to regulate lipolysis in a metabolic dysregulated visceral adipose tissue, even during times of nutrient excess [17]

Additionally, the clinical irrelevance of sKlotho in AAC was demonstrated in this study in a multivariate regression analysis (Krishnasamy et al., 2017)