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[DOI] [PMC free article] [PubMed] [Google Scholar] 296.Pories W.J

Effect of semaglutide treatment on a proteomic signature of secondary CVD risk Previous work generated and validated a 27-protein signature predicting a 4-year likelihood of myocardial infarction, stroke, heart failure or death in patients with established CVD 22

Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

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