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In participants with type 2 diabetes, treatment with retatrutide resulted in a placebo-adjusted least-squares mean weight reduction of 8.96 kg (approximately 10%) in the highest-dose 12 mg group after just 12 weeks

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15,62 The Gly4D-Ala derivative of exendin-4 had similar potency to exendin-4 itself in inducing conformational changes in the heterotrimeric G protein, albeit with modestly lower maximal response, while the Gly4( S,S )-ACPC derivative of exendin-4 was markedly less potent (Fig

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