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4.2 Lack of specific biomarkers and translational limitations of therapeutics The clinical translation of ferroptosis-targeted strategies is bottlenecked by two critical barriers: the absence of specific, standardized biomarkers for ferroptosis in renal tissues and biofluids, and the suboptimal pharmacokinetic and safety profiles of current ferroptosis modulators

Weight loss injections are generally safe for most individuals and can be particularly advantageous for those with a BMI of 27 or higher, or for those facing weight-related health concerns such as type 2 diabetes or high blood pressure

Later, patients using these drugs reported unexpected weight loss due to reduced appetite, which shifted their use from diabetes treatment to mainstream weight-management therapy