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Clearly, distinct sequence and structural features of tirzepatide and peptide 20 allow them to exert combinatorial agonism at two or more receptors at the same time thereby maximize the benefit of polypharmacology and minimize the limitation of mono-targeting

The PlexusDx Precision Peptide Genetic Test identifies whether your GLP1R rs6923761 and GIPR rs1800437 variants favor slower initial response, helping your provider optimize treatment timing

doi: 10.1016/j.dsx.2018.09.010 26 YokoyamaHEmotoMFujiwaraSMotoyamaKMoriokaTKomatsuMet al

The conversation is mostly about coordinating timing if you also pursue clinical treatments (filler, Botox, biostimulators)