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When it was found that foods containing NAD+ precursors, particularly vitamin B3, may treat the fatal illness pellagra, which is characterized by diarrhea, dermatitis, dementia, and death, the clinical significance of maintaining NAD+ levels was established in the early 1900s

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0.25 to 0.5 mg Once or twice daily 4 to 8 weeks Subcutaneous, 1 to 2 inches from lateral epicondyle Moderate to severe lateral epicondylitis, chronic cases Starting with a conservative dose makes sense for most people