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The Endocrine Society's 2023 Obesity Pharmacotherapy Guidelines note that agents producing greater than 15% weight reduction offer meaningfully better long-term weight maintenance and comorbidity resolution, and encourage clinicians to consider switching when initial therapy produces less than 5% weight reduction at 6 months [17]

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This includes a focus on protein, fiber, healthy fats, and keeping sodium in check while prioritizing healthy fats all of which are compatible with GLP-1 use as well

There is no clinical research that supports the safety or benefits of a twice-weekly Ozempic schedule