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In fact, the addition of metformin 1000 mg BID to liraglutide 1.2 mg/day was more effective than liraglutide alone in reducing body weight and BMI after 12 weeks of treatment [60]

Related complications such as kidney disease, retinopathy, cardiovascular events, neurological disorders, bone loss, and bone fragility would severely reduce the patients quality of life (Schwartz et al., 2011)

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Weight loss itself may reduce strain on the skeletal system and improve mobility in daily activities, though patients emphasize that semaglutide does not treat fibromyalgia itself but rather addresses comorbid obesity that may worsen symptoms