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Disrupted BDNF synthesis reduces synaptic plasticity (46), as well as glutamate and other excitatory neuron responses, which may contribute to the pathogenesis of depression (22)

Following intravaginal administration of radiolabeled clotrimazole in patients with normal or inflamed vaginal mucosa, peak serum concentrations of clotrimazole 24 hours after insertion of a single 100 mg tablet of the drug are 0.03 ug/ml and peak serum concentrations 24 hours after administration of a cream containing 50 mg of the drug are 0.01 ug/ml

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