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In the direct comparison of tirzepatide versus semaglutide, we observed CIs compatible with no difference and point estimates indicating a modest numeric advantage of semaglutide, if any, for reducing MACE, particularly among patients at high cardiovascular risk

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We selected nausea, vomiting and diarrhea, widely recognized as adverse effects of GLP-1 RAs, as positive outcome controls [43]

This action causes macrophages to polarize towards an M1 phenotype and lymphocytes mount a cytotoxic T cell response to eliminate target cells 30