ASTN2 deletions are associated with ASD and other neurodevelopmental complications such as attention deficit hyperactivity disorder, OCD, and language delay [96]
Less common, but more serious side effects can include: Pancreatitis Hypoglycemia Allergic reactions (rash, facial swelling, trouble breathing, fainting, rapid heartbeat) Kidney failure Gastrointestinal issues Vision changes Gallbladder issues (stomach pain, fever, jaundice, discolored stool) Differences Mechanism of Action: Semaglutide predominantly functions as a GLP-1 agonist, targeting specific pathways to facilitate its effects
In addition to their glycemic effects, DPP-4 inhibitors have the potential to decrease bone resorption, increase bone formation, and reduce the incidence of osteoporosis and fractures
Limited peptide candidates The molecular weight cutoff and stability requirements mean that only a subset of therapeutic peptides can be delivered sublingually with current technology
