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Safety Profile Well-Tolerated : Semaglutide is generally well-tolerated, with common side effects being gastrointestinal, such as nausea and vomiting, which typically decrease over time

The optimal scheme of organically combining lactate metabolic regulation with other therapies, which includes screening the most effective lactate regulation target, determining the best treatment time window, and identifying the most appropriate action site to maximize antitumor efficacy, remains to be further explored

Int J Mol Sci 24(5)

Under intact PPP and glycolysis with ample glucose and amino acid supply, NADPH can support the xCTmediated cystine uptake [14,48]