Kang MG, Han SW, Kang HR, Hong SJ, Kim DH, Choi JH
In addition, the FDA approved oral semaglutide in 2019, becoming the first oral dosage form of a GLP-1 receptor agonist
A relatively new addition to the arsenal of antidiabetic compounds studied in relation to Type 2 Diabetes mellitus (T2DM) have been the incretin mimetics, a group of substances that appear to work on the glucagon-like peptide-1 (GLP-1) receptor and enhance insulin secretion from the pancreatic -cells in a glucose-dependent manner, possibly more potently in hyperglycemic conditions, while suppressing glucagon secretion at the same time
Senolytics, certain peptides, and some supplement combinations have early-stage human research suggesting potential benefit, but large-scale controlled trials are not yet available