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Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa

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While there may be a slight risk of clumping if the powder is not mixed thoroughly, this does not hinder its efficacy as long as the mixture is consumed in its entirety

The new pre-workout products that L-arginine incorporates are already adding citrulline malate as it raises the levels of arginine in the blood plasma endogenously, to the point of placing them higher than what arginine itself does