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**Tretinoin:** Best for treating acne and deep wrinkles, but may require careful introduction to avoid irritation

Glutamine, glycine, N-acetylcysteine, selenium, whey protein isolates with bonded cysteine, GSH and pro-GSH supplementation improves GSH deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, cognition and surfactant regeneration (301307)

The former preoccupation with stool frequency as an indicator of diarrhoea or constipation has been supplanted by the Bristol stool form scale (BSFS), which provides readily accessible and translatable descriptors, in pictogram format, of stool form, ranging from hard constipated stools (BSFS 1) to watery diarrhoea (BSFS 7), with normality in Western populations lying between BSFS 3 and 5 (ref