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This is not a sudden event

Have a clear relationship between blood concentration and clinical effect

J Hum Genet 55:565570

Ann Rheum Dis 68(2):292293 Fuchs-Telem D, Sarig O, van Steensel MA, Isakov O, Israeli S, Nousbeck J, Richard K, Winnepenninckx V, Vernooij M, Shomron N (2012) Familial pityriasis rubra pilaris is caused by mutations in CARD14