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This article points out the benefits of B12 injections and how long they can last

Researched effects In a diet-induced-obese mouse study (Neelakantan et al., Biochemical Pharmacology, 2018), subcutaneous 5-Amino-1MQ (20 mg/kg, three times daily, roughly 11 days) produced about 5.1% body-weight loss versus continued weight gain in untreated controls, roughly 35% less epididymal white fat mass, smaller adipocytes, lower plasma cholesterol, and improved glucose tolerance, with no reported change in food intake and no observed adverse effects in the mice

Yes, you need a prescription for B12 injections

When administered as a once-weekly subcutaneous injection, tirzepatide enhances insulin secretion in response to elevated blood glucose levels, suppresses inappropriate glucagon release, slows gastric emptying, and promotes satiety through central appetite regulation