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As these medications reduce overall energy intake, individuals are consuming fewer calories with estimates placing this reduction between 16 and 39%, or about 700 calories per day on average (Christensen et al., 2024)

This process is essential for processing environmental toxins and metabolic waste

Further research is necessary to enhance our understanding of these relationships and to investigate novel therapeutic interventions for individuals with vitamin B deficiencies and associated neuropsychiatric symptoms

In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig