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This would suggest that the inability to timely resolve stress conditions and restore homeostasis, rather than the prolonged presence of SGs pushes cells towards irreversible cell death

Menassa M, Stronks K, Khatmi F, Roa Daz ZM, Espinola OP, Gamba M, Itodo OA, Buttia C, Wehrli F, Minder B, Velarde MR, Franco OH (2023) Concepts and definitions of healthy ageing: a systematic review and synthesis of theoretical models

Occurrence of glutathione in bacteria

In the brain, AMPK was shown to be activated by fasting or DR in the hypothalamus (Minokoshi et al., 2004), hippocampus (Dagon et al., 2005), and striatum (Bayliss et al., 2016)