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Specifically, the putative G q -mediated mechanism is thought to involve PKC-mediated activation of an inward depolarising current carried by TRPM4/5 channels (42)

The synthesis of 2-oxyalkyl-cyclohex-2-enones, related to the bioactive natural products COTC and antheminone A, which possess anti-tumour properties

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Moreover, the disruption of the BBB correlates with a loss of tyrosine hydroxylase-positive neurons in the substantia nigra, and although a strong microglial and astroglial response has been detected, the primary cause remains the breakdown of the BBB [301]