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5), and by inference, neurotoxic damage.53 Forgione and colleagues had previously hypothesized that GPX1 deficiency directly induces an increase in vascular oxidative stress, with attendant endothelial dysfunction.54 Glutathione peroxidases, particularly GPx1 have also been implicated in the development and prevention of many common and complex diseases, including cancer and cardiovascular disease (Fig

The lipoproteins of each pool of plasma were isolated sequentially by differential ultracentrifugation at 110 000 g at 20C in a Beckman rotor 60-Ti