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This might be triggered by eating too quickly, consuming certain foods, or by underlying conditions such as irritable bowel syndrome (IBS)

Semaglutide (brand names Ozempic for diabetes, Wegovy for obesity) and tirzepatide (Mounjaro for diabetes, Zepbound for obesity) can produce dramatic weight loss (averaging ~1520% in clinical trials ( [11] )) and lower cardiovascular risk

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These CSPs could be due to direct contacts between the S tail and WD40 domain, reflecting a larger binding footprint for the full-length S tail, or indirect effects such as a loss of long-range intra-tail contacts upon binding to WD40