In a meta-analysis that included 15 RCTs involving a total of 2,330 women, the results also indicated that NAC may have a certain efficacy as an adjunct therapy for infertility related to PCOS and unexplained infertility, particularly in women with high BMI, insulin resistance, and oxidative stress [56]
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Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011