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About three-quarters of users in each group 77% of those taking compounded or custom-mixed medications and 74% of those taking brand-name drugs said the treatments are either "effective" or "extremely effective." Compounded GLP-1 users were slightly more likely to rate the medications as "extremely effective," with 39% reporting that level of effectiveness compared with 32% of brand-name medication users
This rapid turnover makes it unlikely that peripheral GLP-1 significantly contributes to endogenous activation of central GLP-1Rs
It analysed more than 600,000 veterans with type 2 diabetes and, compared with patients on non-GLP-1 medications, being on GLP-1s was associated with being 14% less likely to develop a substance abuse disorder (SUD)
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