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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state

6B), and the electron density less well-defined than in the remaining molecule (Figure S3)

Tirzepatide, which combines GIP and GLP-1 activity, demonstrated approximately 40% greater weight loss than GLP-1 alone, validating the synergistic relationship between these receptors

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