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This synthesis process involves sequential catalysis by tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase (AADC), which progressively convert tyrosine into dopamine (172)

In addition, surface transporters of epithelial cells, such as glucose transporter GLUT2 and amino acid transporter SGLT1, can specifically transport nutrients, further enhancing the selectivity of permeability

The first model developed using four important features from the amino acid composition and achieved maximum R/R 2 of 0.97/0.93 along with MAE 0.07 (Table 4, Additional file 1: Table S2)

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