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In topline results from the largest SURPASS trial to date, using the efficacy estimandi, the highest dose of tirzepatide (15 mg) reduced A1C by 2.46 percent and body weight by 12.4 kg (27.3 lb., 13.1 percent)

6063 Members of the SGLT2i family exhibit cardioprotective effects for patients with atherosclerotic cardiovascular disease

In the Rybelsus trials, gastrointestinal complaints rose with dose: for example, nausea was reported by about 6 percent of people on placebo, 11 percent on the 7 mg tablet, and 20 percent on the 14 mg tablet, and the majority of nausea, vomiting, and diarrhea occurred during dose escalation rather than steady state

c , Homeostatic model assessment of insulin resistance (HOMA-IR) (n = 7 Vhcl, n = 6 GLP-1:Lani, n = 8 GLP-1:GIP:Lani)