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In the nail bed, hyperpigmentation may also be present.43 These habits predispose to complications such as paronychia, transmission of viral warts, and dental alterations including malposition and fractures, as well as oral infections.43 The differential diagnosis includes onychomycosis, psoriasis, lichen planus, chronic paronychia, and nail-patella syndrome, among others.44 Treatment of OCD can be challenging and should include a multidisciplinary approach

Peripherally administered liraglutide has recently been shown to gain access into certain areas of the brain with the majority entering the ARC and median eminence with smaller amounts in the PVN (Secher et al., 2014)

Moreover, multiple other GLP-1/GIP RA in oral or injectable form are in early phase of development (Fig