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The neuroprotective potential of isoquercitrin has been appraised in many studies, as such, one study has found that the oral administration of isoquercitrin protected the hippocampal neurons from streptozotocin (STZ)- induced neurotoxicity in rats ( in vitro model (oxygen-glucose deprivation and reperfusion (OGD/R)) and rat model (middle cerebral artery occlusion and reperfusion (MCAO/R)) (Shi et al., 2021)