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The "gradual decline" group (approximately 40-50% of users) represents modal experience where benefits slowly regress toward pre-treatment baseline over 4-8 months, typically affecting users who completed shorter treatment courses (2-4 months), used lower concentrations or inconsistent application, possessed moderate to severe baseline skin damage requiring ongoing support, maintained adequate but not optimal complementary skincare, experienced significant lifestyle stressors affecting skin health including poor sleep or high stress, and faced genetic or age-related collagen production limitations

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We would have to consider it as a new topic and I believe the company would have to apply for an extension to their marketing authorisation, they added

According to the international consensus on diagnosing and managing dumping syndrome [52], the minimum dose of acarbose indicated for maintenance therapy is 150 mg/day