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Intervention: 30mg icatibant subcutaneously Comparison: Intravenous prednisolone 500 mg and clemastine 2 mg Outcome: Primary: Medium time to complete resolution of edema as evaluated by investigator-assessed and patient assessed symptom score Secondary: Proportion of patients who did not have response to treatment, proportion of patients with complete resolution of edema at 4 hours, time to onset of symptom relief Safety: Incidence of and time to rescue intervention, adverse-event reporting, documentation of local (injection-site) reactions, measurement of vital signs and clinical laboratory testing Authors Conclusions : Among patients with ACE-inhibitorinduced angioedema, the time to complete resolution of edema was significantly shorter with icatibant than with combination therapy with a glucocorticoid and an antihistamine. Quality Checklist for Randomized Clinical Trials: The study population included or focused on those in the ED