Gonzalez HC, Myers DT, Venkat D
For a deeper look at why dose escalation creates problems long-term, read our post on why higher GLP-1 doses don't always produce better long-term results
15,20 Serious GI AEs, though uncommon, have also been reported with GLP-1 RA therapy, including gastroparesis, intestinal obstruction, pancreatitis, and colonic ischemia
When to talk to your healthcare provider Contact your prescribing physician or healthcare provider if constipation persists despite fiber supplementation and complementary strategies for more than 3 weeks, if you experience severe abdominal pain, if you notice blood in your stool, if you develop symptoms of bowel obstruction (vomiting, inability to pass gas, severe abdominal distension), or if constipation is significantly impacting your quality of life or making you consider discontinuing your GLP-1 medication