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The most common complaints are nausea, constipation, headache, insomnia, and a bump in blood pressure and heart rate and nausea is actually the top reason people stop taking it

RBCs, Red blood cells

Sitagliptin and Metformin Coadministration in Patients with Type 2 Diabetes Inadequately Controlled on Diet and Exercise Table 1 summarizes the most common (5% of patients) adverse reactions reported (regardless of investigator assessment of causality) in a 24-week placebo-controlled factorial study in which sitagliptin and metformin were coadministered to patients with type 2 diabetes inadequately controlled on diet and exercise

Its part of why the formula doesnt feel thick or heavy