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In DIO rats, RM-718 demonstrated comparable activity to setmelanotide on weight and food intake reduction in a 14-day study (130)

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Intervention with the therapeutic drug, amifostine (AMI), can reduce DNA damage and ROS levels in cells and the ratio of RANKL to OPG, inhibit the maturation and differentiation of osteoclasts, and has a bone protective effect (222).Osteoclasts cause ROS accumulation during bone resorption or increased RANKL expression (223)