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Mutations in mtDNA or the direct impact of proinflammatory mediators such cytokines, prostaglandins, ROS, and nitric oxide may contribute to mitochondrial dysfunction in chondrocytes in KOA (Kim J

References Frost C, Nepal S, Wang J, et al

Stress and Sleep Chronic stress triggers the release of cortisol, which can increase oxidative damage over time

Na+/K+ pumps work harder to reestablish the normal ionic gradient, but this requires cellular energy in the form of adenosine triphosphate, or ATP (Step 4)