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Accordingly, drug-mediated regulation of Wnt/-catenin signalling activity to induce liver regeneration would benefit this group of patients based on the key role of Wnt/-catenin signalling in the pathobiology of non-tumour diseases such as steatohepatitis, 78,310 cholestasis, 311 and liver fibrosis

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35Pharma is currently developing HS135, a multi-specific receptor ectodomain ligand trap designed to neutralize activins & GDFs, which according to the company are clinically validated drivers of cardiopulmonary and metabolic disease