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Activation of GLP-1Rs on the immune cells results in reduced expression of various inflammatory signaling pathways like nod-like receptor pyrin 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-B) with subsequent inhibition release of pro-inflammatory cytokines like IL-6 and tumor necrosis factor-alpha (TNF-) (Wan and Sun 2019

Consuming five or six smaller portions throughout the day, rather than three large meals, may prevent the stomach from becoming overly full

Weight changes and antibody formation rates are also comparable, supporting the interchangeable nature of these treatments as long as they are properly supervised by healthcare providers

The success of GLP-1RAs in decreasing motivation for food rewards sparked curiosity in whether this decrease in motivation could be applied to substance use disorder