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Each of these treatments has its own advantages & disadvantages, & the choice depends on various factors, like the severity of the disease, the patients age, preference, medical history and availability of resources

As a result, drugs in this class are FDA recommended for use only in RA patients who have failed to respond to TNF bDMARDs (Cohen 2023)

Estradiol has been shown to impact this central CCK expression

And so I think we have to think about, as youre saying, this ecosystem, the digestive system, is not separate from the autonomic nervous system, from the gut microbiome, from the nervous system in general, from the immune system