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Supozitoarele furnizeaz rezultate similare cu cele ale metodelor intravenoase de administrare (putnd obine circa 70% 80% rat de absorbie, comparativ cu metodele intravenoase), dat fiind faptul c ingredientele din supozitor sunt absorbite de peretele rectului i sunt purtate direct n circulaia sistemic (eludnd sistemul circulatoriu enterohepatic unde ingredientele sunt descompuse n ficat)