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Triggers the full exercise-adapted gene program: strongly upregulates mitochondrial biogenesis, fatty acid oxidation, oxidative phosphorylation, angiogenesis, and type I (slow-twitch, fatigue-resistant) muscle fiber genes, almost identical to the transcriptional changes seen after endurance training

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The STEP 1 trial, published in the New England Journal of Medicine, showed that participants taking 2.4mg of semaglutide lost an average of 14.9% of their body weight over 68 weeks, significantly more than the placebo group

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