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There was an increase in the mean pulse rate at the end of treatment in all of the renal function groups but there was no trend towards a greater increase with increasing degree of renal impairment

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Hormone delivery method optimization Before starting a GLP-1 medication, evaluate your HRT delivery method: If you are on oral HRT: Talk to your provider about switching to transdermal delivery (patches or gels) for estrogen, and either a Mirena IUD or transvaginal delivery for progesterone

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