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The study was conducted with data from the COVID-19Associated Hospitalization Surveillance Network (COVID-NET) and showed that adults aged 65 years have increased risk for COVID-19associated hospitalization and other severe outcomes, compared to younger age groups

However, it is not clear what contributed specifically to this effect on inflammation, though increasing evidence suggests that IGF-1 signaling is critical for maintaining immune cell homeostasis 44 , but the prospects of sex differences in the requirement for IGF-1 signaling in these cells is not yet known and will require further study